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PP 242

CAT: 0013-GTR19163687-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163687-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively; shows no activity against PKC-β, RET, or JAK2 but inhibits PKC-α (IC50=50 nM) ; blocks the phosphorylation of Akt at S473 and prevents its full activation, inhibits proliferation of primary cells more completely than rapamycin.
CAS Number
1092351-67-1
Product Name Alternative
PP242 | PP-242
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OC1=CC2=C (NC (C3=NN (C (C) C) C4=NC=NC (N) =C43) =C2) C=C1
Molecular Formula
C16H16N6O
Molecular Weight
308.3378
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indol-5-ol, 2-[4-amino-1- (1-methylethyl) -1H-pyrazolo[3,4-d]pyrimidin-3-yl]-

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