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Takinib

CAT: 0013-GTR19163647-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163647-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Takinib is a potent, selective TAK1 inhibitor with IC50 of 9.5 nM, selectively induces apoptosis following TNF-a stimulation; weakly inhibits IRAK4, IRAK1, GCK, CLK2, and MINK1 with IC50 of 120-430 nM against the MRC Dundee kinase panel, does not inhibit any of the MAP2Ks or MAP3Ks family members; inhibits phosphorylation of IKK, MAPK 8/9, and c-Jun, induces apoptosis in RA fibroblast-like synoviocytes and reduces IL-6 secretion, induces TNF-α-dependent cell death in rheumatoid arthritis and breast cancer cells.
CAS Number
1111556-37-6
Product Name Alternative
Takinib | EDHS-206 | EDHS 206 | EDHS206
Purity
>98% (HPLC)
Solubility
DMSO: 6.8 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1=CC=CC (C (NC2=NC3=CC=CC=C3N2CCC) =O) =C1) N
Molecular Formula
C18H18N4O2
Molecular Weight
322.368
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,3-Benzenedicarboxamide, N1- (1-propyl-1H-benzimidazol-2-yl) -

Alternative Products

CatalogName
BA2736-10Takinib

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