Products for Research Use Only
RegisterLogin

Letrozole

CAT: 0013-GTR19163626-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19163626-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast Y Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. (In Vitro) :Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner.Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation.Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells (In Vivo) :Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats.
CAS Number
112809-51-5
Product Name Alternative
CGS 20267
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 57 mg/mL (199.78 mM)
Smiles
N#CC1=CC=C (C (C2=CC=C (C#N) C=C2) N3N=CN=C3) C=C1
Molecular Formula
C17H11N5
Molecular Weight
285.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[ (4-cyanophenyl) - (1,2,4-triazol-1-yl) methyl]benzonitrile

Chemical Information

Letrozole

Letrozole is a nitrile and a member of triazoles. It has a role as an antineoplastic agent and an EC 1.14.14.14 (aromatase) inhibitor.

CAS Number112809-51-5
PubChem CID3902
IUPAC Name4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
Molecular FormulaC17H11N5
Molecular Weight285.30
XLogP2.7
Topological Polar Surface Area78.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity420
SMILES
C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
InChI
InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChIKey
HPJKCIUCZWXJDR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Letrozole
CAS: 112809-51-5
CID: 3902
Formula: C17H11N5
MW: 285.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight285.30
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass285.10144537
Monoisotopic Mass285.10144537
Topological Polar Surface Area78.3 Ų
Heavy Atom Count22
Formal Charge0
Complexity420
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A1307-5.1Letrozole

Popular Products