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Q-VD-Oph

CAT: 0013-GTR19163610-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163610-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Q-VD-Oph is a potent pan-caspase inhibitor, inhibits human recombinant caspase-7 with IC50 of 48 nM in cell-free assay, also inhibits caspase -1, 3, 8, 9, 10, and 12 with IC50 of 25-400 nM; reduces doxorubicin-induced caspase-3 activation, increases expression of p21/WAF1 and senescence -associated -beta-galactosidase activity, but does not alter Akt activation, Q-VD-Oph is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk; prevents activated caspase-7 and caspase-cleaved fragments of tau in the TgCRND8 brain, as well as pathology associated with TgCRND8 mice.
CAS Number
1135695-98-5
Product Name Alternative
QVD-OPH | Quinoline-Val-Asp-Difluorophenoxymethylketone
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 25 mg/mL
Smiles
O=C (O) C[C@H] (NC ([C@@H] (NC (C1=NC2=CC=CC=C2C=C1) =O) C (C) C) =O) C (COC3=C (F) C=CC=C3F) =O
Molecular Formula
C26H25F2N3O6
Molecular Weight
513.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pentanoic acid, 5- (2,6-difluorophenoxy) -3-[[ (2S) -3-methyl-1-oxo-2-[ (2-quinolinylcarbonyl) amino]butyl]amino]-4-oxo-, (3S) -

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CatalogName
T0282-01Q-VD-OPH

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