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Telotristat etiprate

CAT: 0013-GTR19163605-01Size: 1 gDry Ice: NoHazardous: No
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Description
Telotristat etiprate (LX1606 hippurate) is an orally active, small-molecule inhibitor of peripheral serotonin synthesis, acts by inhibiting tryptophan hydroxylase (TPH) with IC50 of 28 nM, demonstrates potential for the treatment of carcinoid syndrome.Gastric Cancer Approved (In Vivo) :Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS) -induced colitis.
CAS Number
1137608-69-5
Product Name Alternative
LX1606 Hippurate
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 28 mg/mL
Smiles
CCOC (=O) C (CC1=CC=C (C=C1) C2=CC (=NC (=N2) N) OC (C3=C (C=C (C=C3) Cl) N4C=CC (=N4) C) C (F) (F) F) N.C1=CC=C (C=C1) C (=O) NCC (=O) O
Molecular Formula
C36H35ClF3N7O6
Molecular Weight
754.1546
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Phenylalanine, 4-[2-amino-6-[ (1R) -1-[4-chloro-2- (3-methyl-1H-pyrazol-1-yl) phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester, compd. with N-benzoylglycine (1:1)

Chemical Information

Telotristat Etiprate

Telotristat Etiprate is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug, with potential antiserotonergic activity. Upon administration, telotristat etiprate is converted to its active moiety, telotristat (LP-778902), which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.

CAS Number1137608-69-5
PubChem CID25253377
IUPAC Name2-benzamidoacetic acid;ethyl (2S)-2-amino-3-[4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl]phenyl]propanoate
Molecular FormulaC36H35ClF3N7O6
Molecular Weight754.2
Topological Polar Surface Area198
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count13
Heavy Atom Count53
Formal Charge0
Complexity1020
SMILES
CCOC(=O)[C@H](CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)O[C@H](C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N.C1=CC=C(C=C1)C(=O)NCC(=O)O
InChI
InChI=1S/C27H26ClF3N6O3.C9H9NO3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37;11-8(12)6-10-9(13)7-4-2-1-3-5-7/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35);1-5H,6H2,(H,10,13)(H,11,12)/t20-,24+;/m0./s1
InChIKey
XSFPZBUIBYMVEA-CELUQASASA-N
Chemical Structure
2D Structure
2D structure of Telotristat Etiprate
CAS: 1137608-69-5
CID: 25253377
Formula: C36H35ClF3N7O6
MW: 754.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight754.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count13
Exact Mass753.2289440
Monoisotopic Mass753.2289440
Topological Polar Surface Area198 Ų
Heavy Atom Count53
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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M10482-01Telotristat etiprate
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A10542-25Telotristat etiprate (LX 1606 Hippurate) 25mg
A10542-2Telotristat etiprate (LX 1606 Hippurate) 2mg
A10542-500Telotristat etiprate (LX 1606 Hippurate) 500mg
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