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Dofetilide

CAT: 0013-GTR19163572-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163572-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dofetilide is a selective potassium channel ((hERG) ) blocker, used as a Class III antiarrhythmic drug. (In Vitro) :Dofetilide (3~100 μg/kg; i.v.) increases repolarisation time via a selective prolongation of activation repolarisation interval, activation time being unchanged.Dofetilide is metabolized by CYP3A4 to a mixture of inactive polar metabolites that are then excreted by the kidney.
CAS Number
115256-11-6
Product Name Alternative
Tikosyn | UK 68789
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:88 mg/mL warmed (199.29 mM) ; Ethanol:<1 mg/mL (<1 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
CS (=O) (NC1=CC=C (OCCN (CCC2=CC=C (NS (=O) (C) =O) C=C2) C) C=C1) =O
Molecular Formula
C19H27N3O5S2
Molecular Weight
441.56
References & Citations
JJA Bavel et al Drug and device testing in a preclinical model sensitive to cardiac arrhythmias dspace.library.uu.nl, (2023)
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- (2- (methyl (2- (4- (methylsulfonamido) phenoxy) ethyl) amino) ethyl) phenyl) methanesulfonamide

Alternative Products

CatalogName
A8417-5.1Dofetilide

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