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A66

CAT: 0013-GTR19163556-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163556-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively; displays little to no activity against p110β/γ/δ (IC50>3,000 nM), as well as class-III PI3Ks, mTOR, DNA-PK, and PI4Kα/β; induces reduction in focus formation CEF by the highly transforming iSH2 mutants KS459delN, DKRMNS560del, and K379E, blocks PI3K signalling and tumour growth in certain cell types.
CAS Number
1166227-08-2
Product Name Alternative
A 66 | A-66
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1[C@H] (C (N) =O) CCC1) NC2=NC (C) =C (C3=CSC (C (C) (C) C) =N3) S2
Molecular Formula
C17H23N5O2S2
Molecular Weight
393.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2-Pyrrolidinedicarboxamide, N1-[2- (1,1-dimethylethyl) -4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S) -

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