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AMG-337

CAT: 0013-GTR19163551-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163551-01Size:500 mg
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Description
AMG-337 is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM; inhibits of HGF-mediated MET phosphorylation in PC3 cells; shows desirable preclinical pharmacokinetics, significant inhibition of MET phosphorylation in mice, and robust tumor growth inhibition in a MET-dependent mouse efficacy model.Gastric Cancer Phase 2 Clinical (In Vitro) :AMG 337 (0-3 μM; 72 h) inhibits proliferation in MET-dependent cancer cell lines.AMG 337 (0-300 nM; 0-24 h; MKN-45, SNU-620, and SNU-5 cells) inhibits signaling through the PI3K and MAPK pathways in MET-amplified gastric cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis. (In Vivo) :AMG 337 (0-30 mg/kg; p.o.; daily, for 28 d) inhibits MET signaling in tumor xenografts and inhibits tumor growth in MET-dependent tumor xenograft models.AMG 337 (0-3 mg/kg; p.o.; once, for 3 or 24 h) is associated with increased necrosis in the MET-dependent SNU-620 tumor xenograft model.
CAS Number
1173699-31-4
Product Name Alternative
AMG337 | AMG 337
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=C1C2=C (N=CC (OCCOC) =C2) C=CN1[C@@H] (C3=NN=C4C (F) =CC (C5=CN (C) N=C5) =CN43) C
Molecular Formula
C23H22FN7O3
Molecular Weight
463.4643
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,6-Naphthyridin-5 (6H) -one, 6-[ (1R) -1-[8-fluoro-6- (1-methyl-1H-pyrazol-4-yl) -1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3- (2-methoxyethoxy) -

Chemical Information

Amg-337

AMG-337 is under investigation in clinical trial NCT03147976 (QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors).

CAS Number1173699-31-4
PubChem CID44181686
IUPAC Name6-[(1R)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one
Molecular FormulaC23H22FN7O3
Molecular Weight463.5
XLogP1.5
Topological Polar Surface Area99.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity760
SMILES
C[C@H](C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=C(C4=O)C=C(C=N5)OCCOC
InChI
InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1
InChIKey
DWHXUGDWKAIASB-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of Amg-337
CAS: 1173699-31-4
CID: 44181686
Formula: C23H22FN7O3
MW: 463.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.5
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass463.17681575
Monoisotopic Mass463.17681575
Topological Polar Surface Area99.7 Ų
Heavy Atom Count34
Formal Charge0
Complexity760
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A16400-10AMG 337 10mg
A16400-200AMG 337 200mg
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