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Azithromycin dihydrate

CAT: 0013-GTR19164457-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164457-01Size:100 mg
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Description
Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. (In Vitro) :Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM) -enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells. (In Vivo) :Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice.
CAS Number
117772-70-0
Product Name Alternative
Azitro | CP 62993 | CP-62993 | CP62993 | Goxal
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 100 mg/mL (127.38 mM) ; Water: 10 mg/mL (12.73 mM) ; DMSO: 100 mg/mL (127.38 mM)
Smiles
CC[C@@H]1[C@@] (C) (O) [C@H] (O) [C@@H] (C) N (C) C[C@H] (C) C[C@@] (C) (O) [C@H] (O[C@H]2[C@H] (O) [C@@H] (N (C) C) C[C@@H] (C) O2) [C@@H] (C) [C@H] (O[C@H]3C[C@@] (C) (OC) [C@@H] (O) [C@H] (C) O3) [C@@H] (C) C (O1) =O.O.O
Molecular Formula
C38H72N2O12·2H2O
Molecular Weight
785.03
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R) -11- (((2S,3R,4S,6R) -4- (dimethylamino) -3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl) oxy) -2-ethyl-3,4,10-trihydroxy-13- (((2R,4R,5S,6S) -5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl) oxy) -3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one dihydrate

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