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MK-8617

CAT: 0013-GTR19164224-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164224-02Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively; shows no significant inhibition on the cytochrome p450 enzymes; exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.
CAS Number
1187990-87-9
Product Name Alternative
MK 8617 | MK8617
Purity
>98% (HPLC)
Solubility
DMSO: 16 mg/mL (36.1 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
COC1=CC=C (C=C1) C (C2=CC=C (C=C2) OC) NC (=O) C3=CN=C (NC3=O) C4=NN=CC=C4
Molecular Formula
C24H21N5O4
Molecular Weight
443.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide

Chemical Information

MK-8617
CAS Number1187990-87-9
PubChem CID44230662
IUPAC NameN-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide
Molecular FormulaC24H21N5O4
Molecular Weight443.5
XLogP2.4
Topological Polar Surface Area115
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity730
SMILES
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4
InChI
InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31)
InChIKey
WXLPERVDMILVIF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MK-8617
CAS: 1187990-87-9
CID: 44230662
Formula: C24H21N5O4
MW: 443.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.5
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass443.15935417
Monoisotopic Mass443.15935417
Topological Polar Surface Area115 Ų
Heavy Atom Count33
Formal Charge0
Complexity730
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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