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MRT67307

CAT: 0013-GTR19164179-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164179-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells; the autophagy-inhibiting capacity of MRT67307 is specifically through ULK1, results in accumulation of stalled early autophagosomal structures in treated cells; increases IL-10 production and suppresses proinflammatory cytokine production in macrophages, increases CREB-dependent gene transcription by promoting the dephosphorylation of CRTC3; also inhibits MARK, NUAK and SIK isoforms in vitro with comparable potency to the IKK-related kinases.
CAS Number
1190378-57-4
Product Name Alternative
MRT 67307 | MRT-67307
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1CC (C1) C (=O) NCCCNC2=NC (=NC=C2C3CC3) NC4=CC=CC (=C4) CN5CCOCC5
Molecular Formula
C26H36N6O2
Molecular Weight
464.603
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3- (4-morpholinylmethyl) phenyl]amino]-4-pyrimidinyl]amino]propyl]-

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