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Dabrafenib

CAT: 0013-GTR19163979-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163979-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf (wt) and c-Raf, respectively. (In Vitro) :Dabrafenib (GSK2118436, 1 μM) with 0.01 μM GSK1120212 inhibits more than 90% of cell growth in the NRAS mutant clones. GSK2118436 is sufficient to reduce S6P phosphorylation in A375. Dabrafenib suppresses the PolyP-mediated vascular barrier permeability, upregulation of inflammatory biomarkers, adhesion/migration of leukocytes, and activation and/or production of nuclear factor-κB, tumor necrosis factor-α, and interleukin-6. Dabrafenib inhibits the release of HMGB1 and downregulates HMGB1-dependent inflammatory responses by enhancing the expressions of cell adhesion molecules (CAMs) in human endothelial cells. (In Vivo) :Dabrafenib-treated females have mostly immature reproductive tracts with no evidence of ovulation, similar to age-matched controls; however, DAB-treated females have keratinized and histologically open vaginas.
CAS Number
1195765-45-7
Product Name Alternative
GSK2118436
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 30 mg/mL (57.74 mM)
Smiles
CC (C) (C) C1=NC (=C (S1) C1=NC (N) =NC=C1) C1=C (F) C (NS (=O) (=O) C2=C (F) C=CC=C2F) =CC=C1
Molecular Formula
C23H20F3N5O2S2
Molecular Weight
519.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
D072-25MGDabrafenib

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