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Glumetinib

CAT: 0013-GTR19163702-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163702-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glumetinib (SCC 244) is a novel potent and highly selective inhibitor of c-Met kinase with IC50 of 0.42 nM; displays high selectivity versus 312 other tested protein kinases; profoundly and specifically inhibits c-Met signal transduction and suppresses the c-Met-dependent neoplastic phenotype of tumor and endothelial cells; exhibits robust in vivo antitumor activity in NSCLC and hepatocellular carcinoma models.Lung Cancer Preclinical (In Vitro) :Glumetinib (SCC244) (0-10 nM; 72 hours) elicits selective and profound effects against c-Met–driven cancer cell proliferation.Glumetinib (0-50 nM; 24 hours) induces G1–S phase cell-cycle arrest in c-Met–addicted human cancer cells. (In Vivo) :Glumetinib (2.5-10 mg/kg; p.o.; once daily for 2-3 weeks) significantly inhibits c-Met–driven tumor growth in cancer CDX models.Glumetinib shows significant antitumor efficiency in NSCLC and HCC tumor PDX models with MET aberration.
CAS Number
1642581-63-2
Product Name Alternative
SCC244 | SCC 244
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=S (N1N=CC2=NC=C (C3=CN (C) N=C3) C=C21) (C4=CN=C5C=CC (C6=CN (C) N=C6) =CN54) =O
Molecular Formula
C21H17N9O2S
Molecular Weight
459.488
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- (1-Methyl-1H-pyrazol-4-yl) -1-[[6- (1-methyl-1H-pyrazol-4-yl) imidazo[1,2-a]pyridin-3-yl]sulfonyl]-1H-pyrazolo[4,3-b]pyridine

Alternative Products

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BA8877-5Glumetinib
MBS3842794-01Glumetinib (SCC-244)
A18328-1Glumetinib (SCC-244) 1mg
A18328-5Glumetinib (SCC-244) 5mg
A18328-100Glumetinib (SCC-244) 100mg
A18328-50Glumetinib (SCC-244) 50mg
A18328-25Glumetinib (SCC-244) 25mg
A18328-10Glumetinib (SCC-244) 10mg

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