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A-1210477

CAT: 0013-GTR19163879-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163879-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes, shows much weaker against Bcl-2 (Ki=132 nM) and Bcl-XL (Ki>660 nM) ; induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines, synergizes with the BCL-2/BCL-XL inhibitor navitoclax to kill a variety of cancer cell lines; also enhances cobimetinib-induced apoptosis in vitro.
CAS Number
1668553-26-1
Product Name Alternative
A1210477
Purity
>98% (HPLC)
Solubility
DMSO: < 4.8 mg/mL
Smiles
O=C (C (N1CCN2CCOCC2) =C (CCCOC3=C (C=CC=C4) C4=CC=C3) C5=C1C (C6=C (COC7=CC=C (N8CCN (S (=O) (N (C) C) =O) CC8) C=C7) N (C) N=C6C) =CC=C5) O
Molecular Formula
C46H55N7O7S
Molecular Weight
850.0366
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[ (dimethylamino) sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2- (4-morpholinyl) ethyl]-3-[3- (1-naphthalenyloxy) propyl]-

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C12948-5mgA-1210477
BA166475-01A 1210477

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