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BLU-554

CAT: 0013-GTR19163519-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163519-05Size:50 mg
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Description
BLU-554 (Fisogatinib, BLU554) is a novel potent, highly selective and orally bioavailable inhibitor of FGFR4 designed for hepatocellular carcinoma (HCC) with FGFR4 pathway activation; targets FGFR4 while sparing other members of the FGFR family and showing little to no inhibition of all other kinases.Liver Cancer Phase 1 Clinical (In Vivo) :Tissue distribution of Fisogatinib (10 mg/kg; oral gavage; for 4 hours; FVB/NRj mice) in wild-type mice is as follows; tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain. The high Fisogatinib liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver.
CAS Number
1707289-21-1
Product Name Alternative
Fisogatinib | BLU554
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 25 mg/mL
Smiles
COC1=CC (=C (C (=C1Cl) C2=CC3=CN=C (N=C3C=C2) NC4COCCC4NC (=O) C=C) Cl) OC
Molecular Formula
C24H24Cl2N4O4
Molecular Weight
503.3777
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propenamide, N-[ (3S,4S) -3-[[6- (2,6-dichloro-3,5-dimethoxyphenyl) -2-quinazolinyl]amino]tetrahydro-2H-pyran-4-yl]-

Chemical Information

Fisogatinib

Fisogatinib is under investigation in clinical trial NCT04194801 (A Phase Ib/ii Study of Fisogatinib(blu-554) in Subjects With Hepatocellular Carcinoma).

CAS Number1707289-21-1
PubChem CID91885617
IUPAC NameN-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide
Molecular FormulaC24H24Cl2N4O4
Molecular Weight503.4
XLogP4.7
Topological Polar Surface Area94.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity688
SMILES
COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC
InChI
InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1
InChIKey
MGZKYOAQVGSSGC-DLBZAZTESA-N
Chemical Structure
2D Structure
2D structure of Fisogatinib
CAS: 1707289-21-1
CID: 91885617
Formula: C24H24Cl2N4O4
MW: 503.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight503.4
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass502.1174606
Monoisotopic Mass502.1174606
Topological Polar Surface Area94.6 Ų
Heavy Atom Count34
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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