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Bortezomib

CAT: 0013-GTR19163465-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163465-01Size:500 mg
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Description
Bortezomib (PS-341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome; shows only modest activity toward serine and thiol proteases (cathepsin G, elastase, chymotrypsin Ki>300 nM) ; inhibits the TNFα-stimulated activation of NF-κB in primary HUVE cells (IC50=0.5 uM) by blocking the degradation of the inhibitor IκBα; exhibits anti-inflammatory effects in vivo.Blood Cancer Approved (In Vitro) :Bortezomib (PS-341) (100 nM; 8 hours) results in the accumulation of cells in G2-M, with a corresponding decrease in the number of cells in G1.Bortezomib (PS-341) (5-100 nM; 20 hours) induces apoptosis in mantle-cell lymphoma (MCL) cell lines.Bortezomib (PS-341) (20 nM; 1-14 hours) induces Noxa up-regulation in both MCL cell lines.The IC50 of Bortezomib (PS-341) is found to be 2.46 nM for 26S proteasome in the B16F10 cells.Bortezomib (PS-341) suppresses several anti-apoptotic proteins (e.g., Bcl-XL, Bcl-2, and STAT-3) . (In Vivo) :Bortezomib (PS-341) (0.3-1 mg/kg; i.v.; once weekly for 4 weeks) inhibits PC-3 Tumor Growth in Nude Mice.
CAS Number
179324-69-7
Product Name Alternative
PS-341 | PS341 | PS 341
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) C[C@@H] (B (O) O) NC ([C@@H] (NC (C1=NC=CN=C1) =O) CC2=CC=CC=C2) =O
Molecular Formula
C19H25BN4O4
Molecular Weight
384.2372
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Boronic acid, B-[ (1R) -3-methyl-1-[[ (2S) -1-oxo-3-phenyl-2-[ (2-pyrazinylcarbonyl) amino]propyl]amino]butyl]-

Alternative Products

CatalogName
C07434-1gBortezomib

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