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Jaceosidin

CAT: 0013-GTR19163448-06Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163448-06Size:25 mg
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Description
Jaceosidin (4'-Demethyleupatilin, Jaseocidin) is a trihydroxyflavone that exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties; promotes angiogenesis via activation of VEGFR2/FAK/PI3K/AKT/NF-κB signaling pathways in endothelial cells; shows selective suppression of proliferation (IC50 = 82.1 μM in HSC-3 cells and 97.5 μM in Ca9.22 cells) and accumulation of cells at the sub-G1 stage of the cell cycle, induces apoptotic cell death and inhibits the Akt pathway in oral cancer cells.
CAS Number
18085-97-7
Product Name Alternative
4'-Demethyleupatilin | Jaseocidin
Purity
>98% (HPLC)
Solubility
DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C1C=C (C2=CC=C (O) C (OC) =C2) OC3=CC (O) =C (OC) C (O) =C13
Molecular Formula
C17H14O7
Molecular Weight
330.292
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5,7-dihydroxy-2- (4-hydroxy-3-methoxyphenyl) -6-methoxychromen-4-one

Chemical Information

Jaceosidin

Jaceosidin is a trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties. It has a role as a metabolite, an antineoplastic agent, an anti-allergic agent, an anti-inflammatory agent and an apoptosis inducer. It is a dimethoxyflavone and a trihydroxyflavone.

CAS Number18085-97-7
PubChem CID5379096
IUPAC Name5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one
Molecular FormulaC17H14O7
Molecular Weight330.29
XLogP1.7
Topological Polar Surface Area105
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity505
SMILES
COC1=C(C=CC(=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O)O
InChI
InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3
InChIKey
GLAAQZFBFGEBPS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Jaceosidin
CAS: 18085-97-7
CID: 5379096
Formula: C17H14O7
MW: 330.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight330.29
XLogP31.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass330.07395278
Monoisotopic Mass330.07395278
Topological Polar Surface Area105 Ų
Heavy Atom Count24
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A12080-25Jaceosidin 25mg
A12080-1Jaceosidin 1mg

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