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Valdecoxib

CAT: 0013-GTR19163439-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163439-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about possible increased risk of heart attack and stroke. (In Vitro) :Valdecoxib (Compound 2) is a highly potent, selective and orally active inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib (10, 100 μM) inhibits LPS-induced proliferation of endothelial cells and bFGF secretion in a dose-dependent manner. Valdecoxib stimulates VEGF formation via HMEC-1 under inflammatory conditions. (In Vivo) :Valdecoxib (Compound 2) shows potent oral activity in an acute antiinflammatory assay (rat carrageenan foot pad edema; ED50 = 10.2 ± 1.4 mg/kg) . Valdecoxib also has chronic antiinflammatory activity in the rat adjuvant arthritis model, with an ED50 of 0.032 ± 0.002 mg/kg/day. Valdecoxib (10 mg/kg, i.p.) significantly attenuates the behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice.
CAS Number
181695-72-7
Product Name Alternative
Bextra
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 18 mg/mL (57.25 mM) ; DMSO: 63 mg/mL (200.4 mM)
Smiles
CC1=C (C2=CC=C (S (N) (=O) =O) C=C2) C (C3=CC=CC=C3) =NO1
Molecular Formula
C16H14N2O3S
Molecular Weight
314.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (5-methyl-3-phenylisoxazol-4-yl) benzenesulfonamide

Alternative Products

CatalogName
C17400Valdecoxib

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