Pimecrolimus

Pimecrolimus, like all ascomycins, is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12. (In Vitro) :Pimecrolimus (SDZ-ASM 981) (100 nM) targets T-cells and mast cells and inhibits the production and release of cytokines and other inflammatory mediators, as well as the expression of signals essential for the activation of inflammatory T-lymphocytes.Pimecrolimus acts specifically on cells that are crucial for the effector phase of an inflammatory reaction.Pimecrolimus (10 nM; 3 days) inhibits the polyclonal growth of peripheral blood T cells in murine and human mixed lymphocyte reactions.Pimecrolimus inhibits cytokine IL-2, IL-4, IL-10 and interferon-γ release from T-cell clone CFTS4:3.1 with IC50s of 0.28, 0.3, 0.2 and 0.42 nM, respectively after antigen-specific stimulation. (In Vivo) :Pimecrolimus (SDZ-ASM 981) (0-0.4%; topical; 10 μL once) inhibits allergic contact dermatitis in mice and pigs.Pimecrolimus (0-90 mg/kg; p.o. or s.c.; twice or once) potently inhibits allergic contact dermatitis in mice and rats.

137071-32-0

Elidel | SDZ-ASM 981

Pharmacology & Drug Discovery

>98% (HPLC)

Ethanol: 100 mg/mL (123.38 mM) ; DMSO: 100 mg/mL (123.38 mM)

O=C (C (N1CCCC[C@@]1 ([H]) C (O[C@H] (/C (C) =C/[C@H]2C[C@@H] (OC) [C@@H] (Cl) CC2) [C@H] (C) [C@@H] (O) C3) =O) =O) [C@@] (O4) (O) [C@H] (C) C[C@H] (OC) [C@@]4 ([H]) [C@@H] (OC) C[C@@H] (C) C/C (C) =C/[C@@H] (CC) C3=O

C43H68ClNO11

810.45

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.