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Pantoprazole sodium

CAT: 0013-GTR19163341-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163341-01Size:500 mg
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Description
A proton pump inhibitor that inhibits gastric acid secretion; works on gastric parietal cells to irreversibly inhibit (H+/K+) -ATPase function and suppress the production of gastric acid; inhibits autophagy and increases the toxicity of docetaxel in vitro and in vivo.Ulcer Approved (In Vitro) :Pantoprazole sodium (BY1023 sodium; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.Pantoprazole sodium can block exosome release. Pantoprazole sodium inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium (In Vivo) :Pantoprazole sodium (BY1023 sodium; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.Pantoprazole sodium (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats.
CAS Number
138786-67-1
Product Name Alternative
SKF-96022 sodium
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O: ≥ 35 mg/mL
Smiles
COC1=C (C (=NC=C1) CS (=O) C2=NC3=C ([N-]2) C=CC (=C3) OC (F) F) OC.[Na+]
Molecular Formula
C16H14F2N3NaO4S
Molecular Weight
405.3516
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Benzimidazole, 6- (difluoromethoxy) -2-[[ (3,4-dimethoxy-2-pyridinyl) methyl]sulfinyl]-, sodium salt (1:1)

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