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Zanamivir

CAT: 0013-GTR19163337-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163337-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zanamivir is a hihly potent, broad-spetrum influenza viral neuraminidase (NA) inhibitor with IC50 of 0.95 nM and 2.7 nM for influenza A and B, respectively; inhibits plaque formation by laboratory-passaged strains of influenza A and B viruses, IC50 ranging from 0.005 to 0.014 uM; interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions.Influenza Approved (In Vitro) :Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions. (In Vivo) :Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability.
CAS Number
139110-80-8
Product Name Alternative
GG 167 | GR 121167X | Relenza
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O: ≥ 33.33 mg/mL
Smiles
CC (=O) N[C@@H]1[C@H] (C=C (O[C@H]1[C@@H] ([C@@H] (CO) O) O) C (=O) O) N=C (N) N
Molecular Formula
C12H20N4O7
Molecular Weight
332.3098
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
D-glycero-D-galacto-Non-2-enonic acid, 5- (acetylamino) -4-[ (aminoiminomethyl) amino]-2,6-anhydro-3,4,5-trideoxy-

Alternative Products

CatalogName
TRC-Z148000-50MGZanamivir

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