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Mertansine

CAT: 0013-GTR19163322-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163322-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC) ; an ADC payload. (In Vitro) :Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines.Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX. (In Vivo) :Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg.
CAS Number
139504-50-0
Product Name Alternative
DM1 | Maytansinoid DM1 | DM-1 | Maytansinoid DM-1
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 83.33 mg/mL
Smiles
C[C@@H]1[C@@H]2C[C@] ([C@@H] (/C=C\C=C (\CC3=CC (=C (C (=C3) OC) Cl) N (C (=O) C[C@H] ([C@]4 (C1O4) C) OC (=O) [C@H] (C) N (C) C (=O) CCS) C) /C) OC) (NC (=O) O2) O
Molecular Formula
C35H48ClN3O10S
Molecular Weight
738.2877
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Maytansine, N2'-deacetyl-N2'- (3-mercapto-1-oxopropyl) -

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