Amphotericin B

Amphotericin B is a Lipid-based Polyene Antifungal and Polyene Antifungal. The chemical classification of amphotericin b is Polyenes. (In Vitro) :Amphotericin B administration is limited by infusion-related toxicity, including fever and chills, an effect postulated to result from proinflammatory cytokine production by innate immune cells. Amphotericin B induces signal transduction and inflammatory cytokine release from cells expressing TLR2 and CD14. Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K+ leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na+ entry into the cells. (In Vivo) :Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE) . Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice.

1397-89-3

Abelcet | AmBisome | Amphocin | Ampho-Moronal | Amphozone

Pharmacology & Drug Discovery

>98% (HPLC)

DMSO: 22 mg/mL (23.8 mM)

O=C ([C@@H] ([C@] (O1) ([H]) C[C@@H] (O[C@@H]2O[C@H] (C) [C@@H] (O) [C@H] (N) [C@@H]2O) /C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H] (C) [C@@H] (O) [C@@H] (C) [C@H] (C) O3) [C@@H] (O) C[C@@]1 (O) C[C@@H] (O) C[C@@H] (O) [C@H] (O) CC[C@@H] (O) C[C@@H] (O) CC3=O) O

C47H73NO17

924.08

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.