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Ibiglustat

CAT: 0013-GTR19163314-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163314-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access; exhibits significantly lower tissue levels of GL-3 and lyso-GL-3 and a delayed progression of a thermal nociceptive response in administered Fabry mice; shows favorable pharmacological properties and safety profile.Other Indication Phase 2 Clinical (In Vitro) :Ibiglustat (SAR402671) (1 μM, 15 days; Fabry disease (FD) cells) is close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes.
CAS Number
1401090-53-6
Product Name Alternative
Venglustat | Genz-682452 | GZ452
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (O[C@@H]1CN2CCC1CC2) NC (C) (C3=CSC (C4=CC=C (F) C=C4) =N3) C
Molecular Formula
C20H24FN3O2S
Molecular Weight
389.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3S) -1-azabicyclo[2.2.2]octan-3-yl N-{2-[2- (4-fluorophenyl) - 1,3-thiazol-4-yl]propan-2-yl}carbamate

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BA8492-5Ibiglustat
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A21083-5Ibiglustat 5mg
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