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PI-1840

CAT: 0013-GTR19163313-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163313-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI-1840 is a potent, selective, noncovalent, reversible inhibitor for proteasome chymotrypsin-like (CT-L) activity with IC50 of 27 nM, shows no effect on trypsin-like and peptidylglutamyl peptide hydrolyzing activities (IC50>100 uM) ; also displays 100-fold more selectivity for the constitutive proteasome over the immunoproteasome; induces the accumulation of proteasome substrates p27, Bax, and IκB-α, inhibits survival pathways and viability, and induces apoptosis in intact cancer cells, also sensitizes human cancer cells to the mdm2/p53 disruptor Nutlin; suppresses the growth in nude mice of human breast tumor xenografts.
CAS Number
1401223-22-0
Product Name Alternative
PI1840
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCCC1=CC=C (C=C1) OCC (=O) N (CC2=NC (=NO2) C3=CN=CC=C3) C (C) C
Molecular Formula
C22H26N4O3
Molecular Weight
394.4668
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetamide, N- (1-methylethyl) -2- (4-propylphenoxy) -N-[[3- (3-pyridinyl) -1,2,4-oxadiazol-5-yl]methyl]-

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Alternative Products

CatalogName
BGC22322-01PI-1840
462588-01PI 1840
A14146-100PI-1840 100mg
A14146-50PI-1840 50mg
A14146-10PI-1840 10mg
A14146-200PI-1840 200mg
A14146-5PI-1840 5mg
A14146-25PI-1840 25mg
bs-75564C-01PI-1840 [Proteasome Inhibitor]

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