Glycerite

Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS) . The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing. (In Vivo) :During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment.

1401-55-4

Tannic acid | NSC 656273 | NSC-656273

>98% (HPLC)

DMSO: 10 mM

OC1=C (O) C (O) =CC (C (OC2=CC (C (OCC3C (OC (C4=CC (O) =C (O) C (OC (C5=CC (O) =C (O) C (O) =C5) =O) =C4) =O) C (OC (C6=CC (O) =C (O) C (OC (C7=CC (O) =C (O) C (O) =C7) =O) =C6) =O) C (OC (C8=CC (O) =C (O) C (OC (C9=CC (O) =C (O) C (O) =C9) =O) =C8) =O) C (OC (C%10=CC (O) =C (O) C (OC (C%11=CC (O) =C (O) C (O) =C%11) =O) =C%10) =O) O3) =O) =CC (O) =C2O) =O) =C1

C76H52O46

1701.2

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.