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Ilomastat

CAT: 0013-GTR19163249-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163249-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. (In Vitro) :Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with Kis of 0.4 nM, 20 nM, 20 nM, resepctively. Ilomastat (0.1-10 nM) inhibits gelatinase A and gelatinase B produced by T-cells. Ilomastat inhibits T-cell homing. (In Vivo) :Ilomastat (GM6001) (400 μg/mL) inhibits corneal ulceration after severe alkali injury in animals. Ilomastat (GM6001) significantly suppresses intimal hyperplasia and intimalcollagen content. Ilomastat increases lumen area in stented arteries, shows no activity on proliferation rates in rabbit model after stenting.
CAS Number
142880-36-2
Product Name Alternative
GM6001, Galardin
Purity
>98% (HPLC)
Solubility
Ethanol: 8 mg/mL (20.59 mM) ; DMSO: 78 mg/mL (200.79 mM)
Smiles
O=C (NC) [C@@H] (NC ([C@@H] (CC (NO) =O) CC (C) C) =O) CC1=CNC2=CC=CC=C21
Molecular Formula
C20H28N4O4
Molecular Weight
388.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -N1- ((S) -3- (1H-indol-3-yl) -1- (methylamino) -1-oxopropan-2-yl) -N4-hydroxy-2-isobutylsuccinamide

Alternative Products

CatalogName
M11809-01Ilomastat
C12487-5mgIlomastat (GM6001)
HY-15768R-01Ilomastat (Standard)
MBS130458-01GM6001 (galardin, ilomastat)
SF4180-5mgIlomastat (MMP inhibitor)
MBS576658Ilomastat (GM6001, Galardin)
bs-82187C-01Ilomastat (GM-6001)

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