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CPI203

CAT: 0013-GTR19163205-03Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163205-03Size:500 mg
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Description
CPI 203 (TEN 010, JQ-2, RG-6146) is a primary amide analog of (+) -JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM; synergizes the antitumor activity of lenalidomide in bortezomib-resistant mantle cell lymphoma; also enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors, overcomes resistance to ABT-199 (Venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma.
CAS Number
1446144-04-2
Product Name Alternative
TEN 010 | JQ-2 | RG-6146
Purity
>98% (HPLC)
Solubility
DMSO: 72 mg/mL (180 mM) ; Ethanol: 5 mg/mL (12.5 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (N) C[C@H]1C2=NN=C (C) N2C3=C (C (C) =C (C) S3) C (C4=CC=C (Cl) C=C4) =N1
Molecular Formula
C19H18ClN5OS
Molecular Weight
399.897
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(6S) -4- (4-chlorophenyl) -2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

Chemical Information

Cpi-203

a BET protein bromodomain inhibitor

CAS Number1446144-04-2
PubChem CID71291068
IUPAC Name2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamide
Molecular FormulaC19H18ClN5OS
Molecular Weight399.9
XLogP2.9
Topological Polar Surface Area114
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity611
SMILES
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C
InChI
InChI=1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1
InChIKey
QECMENZMDBOLDR-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of Cpi-203
CAS: 1446144-04-2
CID: 71291068
Formula: C19H18ClN5OS
MW: 399.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight399.9
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass399.0920591
Monoisotopic Mass399.0920591
Topological Polar Surface Area114 Ų
Heavy Atom Count27
Formal Charge0
Complexity611
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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