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Pamiparib

CAT: 0013-GTR19163204-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163204-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pamiparib (BGB-290, BGB290) is a highly potent, selective and brain penetrant PARP1/2 inhibitor with potent anti-tumor activity.Ovarian Cancer Phase 2 Clinical (In Vitro) :Pamiparib shows potent DNA-trapping activity with an IC50 of 13 nM. In the cellular assays, Pamiparib inhibits intracellular PAR formation with an IC50 of 0.24 nM. Tumor cell lines with homologous recombination defects are profoundly sensitive to Pamiparib. Pamiparib is highly active both in vitro and in vivo in BRCA mutant tumors. (In Vivo) :Pamiparib suppresses PARP activity in patient-derived glioblastoma multiforme and small-cell-lung cancer xenografts, and potentiates the effects of Temozolamide. In vivo activities of Pamiparib, and its combination activity with chemotherapies in patient biopsy derived small cell lung cancer (SCLC) xenograft models.
CAS Number
1446261-44-4
Product Name Alternative
BGB-290 | BGB 290
Purity
>98% (HPLC)
Solubility
DMSO : 83.3 mg/mL 279.24 mM
Smiles
CC12CCCN1CC3=NNC (=O) C4=C5C3=C2NC5=CC (=C4) F
Molecular Formula
C16H15FN4O
Molecular Weight
298.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(10aR) -2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11- tetraazacyclohepta[def]cyclopenta[a]fluoren-4 (7H) -one

Alternative Products

CatalogName
BA4359-50Pamiparib
HY-104044R-01Pamiparib (Standard)

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