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ABX-1431

CAT: 0013-GTR19163200-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163200-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL) ; displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.Pain Phase 1 Clinical (In Vitro) :Elcubragistat (ABX-1431) is a potent human MGLL inhibitor (IC50=0.014 μM) with >100-fold selectivity against ABHD6 and >200-fold selectivity against PLA2G7. Elcubragistat inhibits human PC3 cells with an IC50 of 0.0022 μM. In the cell-based assay, >100-fold selectivity for MGLL over ABHD6 (IC50=0.253 μM) and PLA2G7 (IC50=494 μM) is maintained. (In Vivo) :Elcubragistat (ABX-1431) inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.
CAS Number
1446817-84-0
Product Name Alternative
ABX1431 | ABX 1431
Purity
>98% (HPLC)
Solubility
DMSO: 100 mg/mL, 197.08 mMWater: InsolubleEthanol: 10 mg/mL, 19.71 mM (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (N1CCN (CC2=CC=C (C (F) (F) F) C=C2N3CCCC3) CC1) OC (C (F) (F) F) C (F) (F) F
Molecular Formula
C20H22F9N3O2
Molecular Weight
507.401
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,1,1,3,3,3-hexafluoropropan-2-yl-4-[[2- (pyrrolidin-1-yl) -4- (trifluoromethyl) phenyl]methyl]piperazine-1-carboxylate

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Alternative Products

CatalogName
MBS5751776ABX-1431
BA167497-01ABX 1431
A18652-2ABX-1431 2mg
M13179ABX-1431 hydrochloride
A18652-10ABX-1431 10mg
A18652-100ABX-1431 100mg
A18652-5ABX-1431 5mg
A18652-50ABX-1431 50mg
A18652-25ABX-1431 25mg
A18652-10mM-DABX-1431 10mM * 1mL in DMSO

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