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Ivosidenib

CAT: 0013-GTR19163193-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163193-01Size:200 mg
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Description
A mutant-selective inhibitor of IDH1 (isocitrate dehydrogenase type 1) ; represent a worthwhile avenue of exploration in the treatment of IDH1-mutated tumors.Blood Cancer Phase 3 Clinical (In Vitro) :Ivosidenib (AG-120) (0-13 μM; 48 hours) inhibits several IDH1-R132 mutants with potency similar IC50 values: IDH1-R132H (IC50=12 nM) ; IDH1-R132C (IC50=13 nM) ; IDH1-R132G (IC50=8 nM) ; IDH1-R132L (IC50=13 nM) ; IDH1-R132S (IC50=12 nM), respectively. (In Vivo) :AG-120 (gavage administration; 50 mg/kg and 150 mg/kg) declines tumor 2-HG concentration rapidly, with maximum inhibition (92.0% and 95.2% at the 50 mg/kg and 150 mg/kg doses, respectively) achieved at -12 h post dose.
CAS Number
1448347-49-6
Product Name Alternative
AG-120
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 39 mg/mL
Smiles
C1CC (=O) N (C1C (=O) N (C2=CC (=CN=C2) F) C (C3=CC=CC=C3Cl) C (=O) NC4CC (C4) (F) F) C5=NC=CC (=C5) C#N
Molecular Formula
C28H22ClF3N6O3
Molecular Weight
582.9609
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Glycinamide, 1- (4-cyano-2-pyridinyl) -5-oxo-L-prolyl-2- (2-chlorophenyl) -N- (3,3-difluorocyclobutyl) -N2- (5-fluoro-3-pyridinyl) -, (2S) -

Alternative Products

CatalogName
BUP16957-01Ivosidenib
TRC-C240800-50MGIvosidenib Isonicotinamide
MBS130807-01Ivosidenib, RG120
C13265-1gIvosidenib (AG-120)
B1163-5AG-120 (Ivosidenib)
462555(R,S)-Ivosidenib
HY-18767A-01(R, S) -Ivosidenib

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