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Gamithromycin

CAT: 0013-GTR19163176-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163176-01Size:1 g
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Description
A macrolide compound with antibacterial activity. (In Vitro) :The MIC values in serum are significantly lower than those in artificial medium; at an initial inoculum size of 106 cfu/mL, these are 64-, 8- and 64-fold lower for gamithromycin, tylosin and tilmicosin, respectively, against MmmSC strain B237 in serum compare to artificial medium. A similar pattern emerges for Tan8. Heat-inactivation of serum results in an MIC for gamithromycin that is higher than in either non-treated serum or artificial medium. (In Vivo) :The proportion of foals that recover without the need for a change in treatment is significantly (P<0.048) higher for foals treated with Gamithromycin (GAM) (38 of 40; 95%) or AZM-RIF (39 of 40; 98%) compare to control foals (32 of 41; 78%) . The clinical scores, number of abscesses and the abscess scores after 1 and 2 weeks of treatment are significantly lower for foals treated with Gamithromycin (GAM) or AZM-RIF compare to control foals. The WBC count of foals treated with Gamithromycin (GAM) is significantly higher than that of foals treated with AZM-RIF on week 3 of treatment.
CAS Number
145435-72-9
Product Name Alternative
ML-1709460
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
O=C1[C@H] (C) [C@@H] (O[C@@H]2O[C@@H] (C) [C@H] (O) [C@] (C) (OC) C2) [C@H] (C) [C@@H] (O[C@@H]3O[C@H] (C) C[C@H] (N (C) C) [C@H]3O) [C@] (C) (O) C[C@@H] (C) N (CCC) C[C@H] (C) [C@@H] (O) [C@] (C) (O) [C@@H] (CC) O1
Molecular Formula
C40H76N2O12
Molecular Weight
777.04
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R) -11-[ (2S,3R,4S,6R) -4- (dimethylamino) -3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[ (2R,4R,5S,6S) -5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one

Alternative Products

CatalogName
BA1074-5Gamithromycin

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