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Azilsartan

CAT: 0013-GTR19163142-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163142-01Size:1 g
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Description
A specific and potent angiotensin II type 1 receptor (AT1) antagonist with IC50 of 2.6 nM, used in the treatment of adults with essential hypertension. Hypertension Approved (In Vitro) :Azilsartan (0-200 μM, 0-72 h) decreases the viability of HepG2 cells.Azilsartan (100 μM, 24 h) induces apoptosis in HepG2 cells.Azilsartan inhibits the specific binding of 125I-Sar1-Ile8-AII to human angiotensin type 1 receptors with an IC50 of 2.6 nM.Azilsartan potently inhibits aortic endothelial and vascular cell proliferation in the absence of exogenous Ang II supplementation.Azilsartan enhances adipogenesis and exerted greater effects than Valsartan (HY-18204) on expression of genes encoding peroxisome proliferator-activated receptor-�� (PPARα), PPARδ, leptin, adipsin, and adiponectin. (In Vivo) :Azilsartan (0-3 mg/kg, Oral gavage, once daily for 5 days) decreases SBP (systolic blood pressure) in obese Koletsky rats at 2 mg/kg.Azilsartan (0-2 mg/kg, Oral gavage, once daily for 21 days) lowers blood pressure and basal plasma insulin concentration.Azilsartan (2 and 4 mg/kg; PO, daily for 9 days) offers protection against ischemia induced secondary brain injury.
CAS Number
147403-03-0
Product Name Alternative
TAK-536
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCOC1=NC2=CC=CC (C (O) =O) =C2N1CC1=CC=C (C=C1) C1=CC=CC=C1C1=NC (=O) ON1
Molecular Formula
C25H20N4O5
Molecular Weight
456.4501
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Benzimidazole-7-carboxylic acid, 1-[[2'- (2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl) [1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-

Alternative Products

CatalogName
HY-14914-01Azilsartan

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