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Pitavastatin calcium

CAT: 0013-GTR19163140-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163140-01Size:500 mg
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Description
Pitavastatin calcium is a novel member of the medication class of statins. The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis. Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM) . It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions. Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure. (In Vitro) :Pitavastatin Calcium inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50 = 0.4-5 μM) or as spheroids (IC50=0.6-4 μM) .Pitavastatin Calcium (1 μM; 48 hours) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells.Pitavastatin (1 μM, 48 hours) causes PARP cleavage in Ovcar-8 cells. (In Vivo) :Pitavastatin Calcium (59 mg/kg; p.o.; twice daily for 28 days) causes significant tumour regression.
CAS Number
147526-32-7
Product Name Alternative
Itabastatin | Itavastatin | NK 104
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 51 mg/mL (57.89 mM)
Smiles
C1C (C1) C2=NC3=CC=CC=C3C (=C2/C=C/[C@@H] (O) C[C@@H] (O) CC (=O) [O-]) C4=CC=C (C=C4) F.C1C (C1) C2=NC3=CC=CC=C3C (=C2/C=C/[C@@H] (O) C[C@@H] (O) CC (=O) [O-]) C4=CC=C (C=C4) F.[Ca+2]
Molecular Formula
C50H46CaF2N2O8
Molecular Weight
880.98
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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