Products for Research Use Only
RegisterLogin

Albamycinsodium

CAT: 0013-GTR19163138-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19163138-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Novobiocin Sodium is an antibiotic compound derived from Streptomyces niveus. (In Vitro) :Bosentan (BOS) competitively and specifically antagonizes binding of 125I-labelled ET-1 to ETA receptors on human smooth muscle cells (SMC) and ETB receptors on human placenta cells. The in vitro binding affinity of Bosentan to ETA receptors on human SMC is 4.7 nM and to ETB receptors on human SMC or placenta cells is 41 or 95 nM. Bosentan has 67-fold greater selectivity for ETA than ETB receptors (mean IC50=7.1 vs 474.8 nM) in an in vitro 125I-labeling assay. (In Vivo) :Single-dose Bosentan 62.5 mg significantly (p<0.01 vs baseline) plasma ET-1 levels by 2-fold in 7 pts with WHO class II or III idiopathic or CTD-associated PAH, with peak levels achieved at 8 h. In hypertensive rats, Macitentan 30 mg/kg further decreases mean arterial blood pressure (MAP) by 19 mm Hg when given on top of Bosentan 100 mg/kg. Conversely, Bosentan given on top of Macitentan fails to induce an additional MAP decrease. In pulmonary hypertensive rats, Macitentan 30 mg/kg further decreases mean pulmonary artery pressure (MPAP) by 4 mm Hg on top of Bosentan, whereas a maximal effective dose of Bosentan given on top of Macitentan does not cause any additional MPAP decrease.
CAS Number
1476-53-5
Product Name Alternative
NSC 2382
Purity
>98% (HPLC)
Solubility
Ethanol: 127 mg/mL (200.12 mM) ; Water: 127 mg/mL (200.12 mM) ; DMSO: 127 mg/mL (200.12 mM)
Smiles
[Na+].CO[C@@H]1[C@@H] (OC (=O) N) [C@@H] (O) [C@H] (Oc2ccc3C (=C (NC (=O) c4ccc (O) c (CC=C (C) C) c4) C (=O) Oc3c2C) [O-]) OC1 (C) C
Molecular Formula
C31H35N2NaO11
Molecular Weight
634.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium 7- (((2R,3R,4S,5R) -4- (carbamoyloxy) -3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl) oxy) -3- (4-hydroxy-3- (3-methylbut-2-en-1-yl) benzamido) -8-methyl-2-oxo-2H-chromen-4-olate

Alternative Products

CatalogName
MBS3602036-01Albamycinsodium

Popular Products