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GNE-3511

CAT: 0013-GTR19163118-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163118-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-3511 is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3; inhibits p-JNK with IC50 of 30 nM, displays concentration-dependent protection of neurons from degeneration in vitro (DRG IC50=107 nM) and demonstrates dose-dependent activity in multiple animal models of neurodegenerative disease.
CAS Number
1496581-76-0
Product Name Alternative
GNE3511 | GNE 3511
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
N#CC1=CC (NC2=NC (N3CC (F) (F) CC3) =CC (C4CCN (C5COC5) CC4) =C2) =NC=C1
Molecular Formula
C23H26F2N6O
Molecular Weight
440.489
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Pyridinecarbonitrile, 2-[[6- (3,3-difluoro-1-pyrrolidinyl) -4-[1- (3-oxetanyl) -4-piperidinyl]-2-pyridinyl]amino]-

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B1341-5GNE-3511
A21457-10GNE-3511 10mg
A21457-5GNE-3511 5mg
A21457-50GNE-3511 50mg
A21457-1GNE-3511 1mg
A21457-100GNE-3511 100mg
A21457-25GNE-3511 25mg
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