Advantame

• Description:

  Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K+ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits[1][2][3].

• UNSPSC:

  12352005

• Target:

  Taste Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/advantame.html

• Purity:

  99.66

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=C(OC)C=CC(CCCN[C@@H](CC(O)=O)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)=C1.O

• Molecular Formula:

  C24H32N2O8

• Molecular Weight:

  476.52

• References & Citations:

  [1]Otabe, A., et al., (2011) . Advantame--an overview of the toxicity data. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 49 Suppl 1, S2–S7. |[2]DENISA IOANA VOICULESCU, et al., (2021) COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS: Farmacia, 69, 6.|[3]EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), (2013), Scientific Opinion on the safety of advantame for the proposed uses as a food additive, 11 (7) .|[4]Skapinker, E., et al., (2024) . Artificial and Natural Sweeteners Biased T1R2/T1R3 Taste Receptors Transactivate Glycosylated Receptors on Cancer Cells to Induce Epithelial-Mesenchymal Transition of Metastatic Phenotype. Nutrients, 16 (12), 1840.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  714229-20-6