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SCR7

CAT: 0013-GTR19163069-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163069-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I; inhibits NHEJ in a Ligase IV-dependent manner within cells, causes accumulation of double-strand breaks (DSBs), and activates the intrinsic apoptotic pathway; decreases cell proliferation of MCF7, A549, and HeLa with IC50 of 40, 34, and 44 uM, respectively; increases the efficacy of DSB-inducing therapeutic modalities in mouse xenografts; increases the efficiency of precise genome editing with CRISPR-Cas9 in mammalian cell lines and in mice.
CAS Number
1533426-72-0
Product Name Alternative
SCR-7
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 45 mg/mL
Smiles
O=C (C (/N=C/C1=CC=CC=C1) =C (/N=C/C2=CC=CC=C2) N3) NC3=S
Molecular Formula
C18H14N4OS
Molecular Weight
334.395
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4 (1H) -Pyrimidinone, 2,3-dihydro-5,6-bis[ (phenylmethylene) amino]-2-thioxo-

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