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2-Deoxy-D-glucose

CAT: 0013-GTR19163054-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163054-01Size:500 mg
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Description
2-Deoxy-D-glucose, an analog of glucose, is a glycolytic inhibitor with antiviral activity. (In Vitro) :2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells. (In Vivo) :2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.
CAS Number
154-17-6
Product Name Alternative
Ba 2758 | NSC 15193
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 1 mg/mL (6.09 mM) DMSO: 32 mg/mL (194.93 mM) Water: 32 mg/mL (194.93 mM)
Smiles
O=CC[C@H] ([C@@H] ([C@@H] (CO) O) O) O
Molecular Formula
C6H12O5
Molecular Weight
164.16
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Deoxy-D-arabinohexose

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