CB-5083

CAT: 0013-GTR19163050-01Size: 1 gDry Ice: NoHazardous: No

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CAT#:0013-GTR19163050-01Size:1 g

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CB-5083 is a potent, selective, orally bioavailable inhibitor of p97 AAA with IC50 of 11 nM, specifically targets D2 ATPase site of p97, shows 9.6, 128 and 158-fold less affinity for DNA-PK, mTOR and PIK3C3; causes accumulation of poly-ubiquitinated proteins, retention of ERAD substrates, and generation of irresolvable proteotoxic stress, leading to activation of the apoptotic arm of the unfolded protein response (UPR) in cancer cells; inhibits A549 cell viability with IC50 of 0.67 uM, induces the UPR and apoptosis in xenograft tumor models.Blood Cancer Phase 1 Clinical.

CAS Number

1542705-92-9

Product Name Alternative

CB5083 | CB 5083

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

O=C (C1=CC=CC2=C1C=C (C) N2C3=NC (NCC4=CC=CC=C4) =C (COCC5) C5=N3) N.

Molecular Formula

C24H23N5O2

Molecular Weight

413.4717

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1H-Indole-4-carboxamide, 1-[7,8-dihydro-4-[ (phenylmethyl) amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-

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B6032-100	CB-5083
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CB-5083

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