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Conatumumab

CAT: 0804-HY-P99260-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99260-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5) . Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3].
CAS Number
896731-82-1
Product Name Alternative
AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody
UNSPSC
12352203
Target
TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/conatumumab.html
Purity
98.90
Solubility
10 mM in DMSO
Smiles
[Conatumumab]
Molecular Weight
(145.44 kDa)
References & Citations
[1]Herbst RS, et al. A first-in-human study of conatumumab in adult patients with advanced solid tumors. Clin Cancer Res. 2010 Dec 1;16 (23) :5883-91. |[2]Kaplan-Lefko PJ, et al. Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. Cancer Biol Ther. 2010 Apr 15;9 (8) :618-31.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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