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Darunavir

CAT: 0013-GTR19162833-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162833-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM; blockes the infectivity and replication of HIV-1 (NL4-3) variants with IC50 of 3-29 nM, also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients; used to treat and prevent HIV/AIDS.HIV Infection Approved (In Vitro) :Darunavir (TMC114, 1a) has a stability comparable to other protease inhibitors.Darunavir (TMC114, UIC-94017) blocks the infectivity and replication of each of HIV-1NL4-3 variants exposed to and selected for resistance to Ro 31-8959, MK-639, AG1341, or ABT 538 at concentrations up to 5 μM (IC50s, 0.003 to 0.029 μM), although it was less active against HIV-1NL4-3 variants selected for resistance to VX-478 (IC50, 0.22 μM) .
CAS Number
206361-99-1
Product Name Alternative
TMC-114 | UIC-94017
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) CN (C[C@H] ([C@H] (CC1=CC=CC=C1) NC (=O) O[C@H]2CO[C@@H]3[C@H]2CCO3) O) S (=O) (=O) C4=CC=C (C=C4) N
Molecular Formula
C27H37N3O7S
Molecular Weight
547.6636
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Carbamic acid, N-[ (1S,2R) -3-[[ (4-aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenylmethyl) propyl]-, (3R,3aS,6aR) -hexahydrofuro[2,3-b]furan-3-yl ester

Alternative Products

CatalogName
A8206-SDarunavir
TRC-D193535-50MG(+)-Darunavir

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