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NM107

CAT: 0013-GTR19162827-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162827-07Size:50 mg
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Description
A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells; The active component of NM283.HCV Infection Phase 2 Discontinued.
CAS Number
20724-73-6
Product Name Alternative
2'-C-Methylcytidine | NM-107 | Valopicitabine
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@H] ([C@@] ([C@H] (N2C (N=C (C=C2) N) =O) O1) (C) O) O
Molecular Formula
C10H15N3O5
Molecular Weight
257.2432
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cytidine, 2'-C-methyl-

Chemical Information

2'-C-Methylcytidine

A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.

CAS Number20724-73-6
PubChem CID500902
IUPAC Name4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
Molecular FormulaC10H15N3O5
Molecular Weight257.24
XLogP-2.4
Topological Polar Surface Area129
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity424
SMILES
C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)O)O
InChI
InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1
InChIKey
PPUDLEUZKVJXSZ-VPCXQMTMSA-N
Chemical Structure
2D Structure
2D structure of 2'-C-Methylcytidine
CAS: 20724-73-6
CID: 500902
Formula: C10H15N3O5
MW: 257.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight257.24
XLogP3-2.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass257.10117059
Monoisotopic Mass257.10117059
Topological Polar Surface Area129 Ų
Heavy Atom Count18
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA1862-100NM107
A21761-10NM107 10mg
A21761-100NM107 100mg
A21761-50NM107 50mg
A21761-25NM107 25mg
A21761-2NM107 2mg
HY-10468R-01NM107 (Standard)
A21761-5NM107 5mg
A21761-10mM-DNM107 10mM * 1mL in DMSO

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