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SEL-201

CAT: 0013-GTR19162809-04Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162809-04Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEL-201 (SLV-2436, SEL201-88) is a novel potent, selective, ATP-competitive and oral MNK1/2 inhibitor with IC5010.8/5.4 nM, respectively; displays acceptable kinome selectivity in the broad KINOMEscan (450 distinct kinases) ; potently suppresses MNK1/2 activity in a panel of KIT-mutant melanoma cell lines, reduces clonogenicity, migration, and lung metastasis of KIT-mutant melanoma cells both in vitro and in vivo.
CAS Number
2095704-43-9
Product Name Alternative
SLV-2436 | SEL201-88
Purity
>98% (HPLC)
Solubility
< 1 mg/ml refers to the product slightly soluble or insoluble
Smiles
C1=CC (=CC (=C1) Cl) CN2C=C (C=CC2=O) C3=CC4=C (C=C3) C (=NN4) N
Molecular Formula
C19H15ClN4O
Molecular Weight
350.806
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (3-amino-1H-indazol-6-yl) -1-[ (3-chlorophenyl) methyl]-1,2-dihydropyridin-2-one

Chemical Information

5-(3-Amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one
CAS Number2095704-43-9
PubChem CID129052025
IUPAC Name5-(3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one
Molecular FormulaC19H15ClN4O
Molecular Weight350.8
XLogP3
Topological Polar Surface Area75
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity578
SMILES
C1=CC(=CC(=C1)Cl)CN2C=C(C=CC2=O)C3=CC4=C(C=C3)C(=NN4)N
InChI
InChI=1S/C19H15ClN4O/c20-15-3-1-2-12(8-15)10-24-11-14(5-7-18(24)25)13-4-6-16-17(9-13)22-23-19(16)21/h1-9,11H,10H2,(H3,21,22,23)
InChIKey
YQVUADHJKWJHAF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(3-Amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one
CAS: 2095704-43-9
CID: 129052025
Formula: C19H15ClN4O
MW: 350.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.8
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass350.0934388
Monoisotopic Mass350.0934388
Topological Polar Surface Area75 Ų
Heavy Atom Count25
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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