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LY-411575

CAT: 0013-GTR19162800-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162800-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent γ-secretase inhibitor that has an IC50 value of 119 pM for reduction of Aβ levels in APP-transfected cell lines; dose dependently reduces Aβ (1-40) and Aβ (1-42) in the brain, CSF, and plasma of Tg2576 mice; reduces cortical Abeta (40) in young transgenic CRND8 mice with ED50 of 0.6 mg/kg, and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg) .Alzheimer's Disease Preclinical.
CAS Number
209984-57-6
Product Name Alternative
LY411575 | LY 411575
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C[C@@H] (C (N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N (C) C1=O) =O) NC ([C@H] (C4=CC (F) =CC (F) =C4) O) =O
Molecular Formula
C26H23F2N3O4
Molecular Weight
479.4753
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, N-[ (1S) -2-[[ (7S) -6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b, d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-.alpha.-hydroxy-, (.alpha.S) -

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Alternative Products

CatalogName
366898LY-411575 (LY 411575, LY411575, Semagacestat)
MBS385100-01LY-411575
FL104120-01LY 411575
A11176-100LY-411575 100mg
A11176-25LY-411575 25mg
A11176-50LY-411575 50mg
A11176-10LY-411575 10mg
A11176-5LY-411575 5mg
A11176-2LY-411575 2mg
T11905-01LY-411575 isomer 3

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