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PD173074

CAT: 0013-GTR19162744-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162744-03Size:10 mg
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Description
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
CAS Number
219580-11-7
Product Name Alternative
PD173074 | PD 173074 | PD-173074
Purity
>98% (HPLC)
Solubility
Ethanol: 100 mg/mL (190.95 mM) ; DMSO: 100 mg/mL (190.95 mM)
Smiles
O=C (NC1=NC2=NC (NCCCCN (CC) CC) =NC=C2C=C1C3=CC (OC) =CC (OC) =C3) NC (C) (C) C
Molecular Formula
C28H41N7O3
Molecular Weight
523.67
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (tert-butyl) -3- (2- ((4- (diethylamino) butyl) amino) -6- (3,5-dimethoxyphenyl) pyrido[2,3-d]pyrimidin-7-yl) urea

Chemical Information

N-(2-((4-(Diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1,1-dimethylethyl)urea

PD173074 is a member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N3 is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a fibroblast growth factor receptor antagonist. It is an aromatic amine, a pyridopyrimidine, a member of ureas, a tertiary amino compound, a dimethoxybenzene and a biaryl. It is functionally related to a PD-166866.

CAS Number219580-11-7
PubChem CID1401
IUPAC Name1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
Molecular FormulaC28H41N7O3
Molecular Weight523.7
XLogP4.5
Topological Polar Surface Area114
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count13
Heavy Atom Count38
Formal Charge0
Complexity690
SMILES
CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
InChI
InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
InChIKey
DXCUKNQANPLTEJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-((4-(Diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1,1-dimethylethyl)urea
CAS: 219580-11-7
CID: 1401
Formula: C28H41N7O3
MW: 523.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight523.7
XLogP34.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count13
Exact Mass523.32708820
Monoisotopic Mass523.32708820
Topological Polar Surface Area114 Ų
Heavy Atom Count38
Formal Charge0
Complexity690
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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