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Zotarolimus

CAT: 0013-GTR19162730-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162730-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin; effectively inhibits both smooth muscle cell and endothelial cell proliferation, with IC50 values of 2.9 nM and 2.6 nM, respectively; exhibits high-affinity binding to the immunophilin FKBP12, inhibiting in vitro proliferation of both human and rat T cells; inhibits Con A-induced human T cells with IC50 of 7.0 nM; reduce early complications and improve late clinical outcomes in patients needing interventional cardiology.
CAS Number
221877-54-9
Product Name Alternative
ABT-578 | A-179578 | ABT578 | A179578 | ABT 578 | A 179578
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
O=C ([C@@] (CCCC1) ([H]) N1C (C ([C@@]2 (O) [C@H] (C) CC[C@@] (O2) ([H]) C[C@H] (OC) /C (C) =C/C=C/C=C/[C@@H] (C) C[C@@H] (C) C ([C@H] (OC) [C@H] (O) /C (C) =C/[C@H]3C) =O) =O) =O) O[C@H] ([C@H] (C) C[C@H]4C[C@@H] (OC) [C@@H] (N5N=NN=C5) CC4) CC3=O
Molecular Formula
C52H79N5O12
Molecular Weight
966.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Rapamycin, 42-deoxy-42- (1H-tetrazol-1-yl) -, (42S) -

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A11950-100Zotarolimus 100mg
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