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Naproxen

CAT: 0013-GTR19162727-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162727-01Size:1 g
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Description
Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. (In Vitro) :Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively. (In Vivo) :Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM) .
CAS Number
22204-53-1
Product Name Alternative
(S) -Naproxen
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Soluble in Ethanol
Smiles
O=C (O) [C@@H] (C) C1=CC=C2C=C (OC) C=CC2=C1
Molecular Formula
C14H14O3
Molecular Weight
230.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -2- (6-methoxynaphthalen-2-yl) propanoic acid

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