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Cediranib

CAT: 0013-GTR19162720-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162720-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively; also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR; inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells; inhibits angiogenesis, neovascular survival and tumor growth in vivo. Ovarian Cancer Phase 3 Clinical.
CAS Number
288383-20-0
Product Name Alternative
AZD2171 | AZD 2171 | AZD-2171
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 49 mg/mL
Smiles
COC1=C (OCCCN2CCCC2) C=C2N=CN=C (OC3=C (F) C4=C (NC (C) =C4) C=C3) C2=C1
Molecular Formula
C25H27FN4O3
Molecular Weight
450.5053
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinazoline, 4-[ (4-fluoro-2-methyl-1H-indol-5-yl) oxy]-6-methoxy-7-[3- (1-pyrrolidinyl) propoxy]-

Chemical Information

Cediranib

4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline is an aromatic ether.

CAS Number288383-20-0
PubChem CID9933475
IUPAC Name4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
Molecular FormulaC25H27FN4O3
Molecular Weight450.5
XLogP4.9
Topological Polar Surface Area72.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity624
SMILES
CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5
InChI
InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
InChIKey
XXJWYDDUDKYVKI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cediranib
CAS: 288383-20-0
CID: 9933475
Formula: C25H27FN4O3
MW: 450.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight450.5
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass450.20671890
Monoisotopic Mass450.20671890
Topological Polar Surface Area72.5 Ų
Heavy Atom Count33
Formal Charge0
Complexity624
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3603882-01Cediranib
206937Cediranib maleate
MBS386036-01Cediranib (AZD2171)
HY-13049-01Cediranib (maleate)

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