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Senicapoc

CAT: 0013-GTR19162716-03Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162716-03Size:5 mg
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Description
A potent, selective Gardos channel blocker that blocks Ca (2+) -induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM) ; shows greater potency and selectivity than Clotrimazole; increases RBC K (+) content and hematocrit (Hct), decreases corpuscular hemoglobin concentration (MCHC) in a transgenic mouse model of sickle cell disease (SAD) ; orally active.Other Indication Phase 3 Discontinued.
CAS Number
289656-45-7
Product Name Alternative
ICA-17043
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1=CC=C (C=C1) C (C2=CC=C (C=C2) F) (C3=CC=C (C=C3) F) C (=O) N
Molecular Formula
C20H15F2NO
Molecular Weight
323.336
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, 4-fluoro-.alpha.- (4-fluorophenyl) -.alpha.-phenyl-

Chemical Information

Senicapoc

Senicapoc is an orally bioavailable inhibitor of the calcium-activated potassium channel KCa3.1 (Gardos channel; KCNN4; IK-1; SK4), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, senicapoc targets, binds to and inhibits KCa3.1.

CAS Number289656-45-7
PubChem CID216327
IUPAC Name2,2-bis(4-fluorophenyl)-2-phenylacetamide
Molecular FormulaC20H15F2NO
Molecular Weight323.3
XLogP4.1
Topological Polar Surface Area43.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity397
SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
InChI
InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey
SCTZUZTYRMOMKT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Senicapoc
CAS: 289656-45-7
CID: 216327
Formula: C20H15F2NO
MW: 323.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass323.11217043
Monoisotopic Mass323.11217043
Topological Polar Surface Area43.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6866-10Senicapoc
CS-O-63473Senicapoc-d4
HY-50694R-01Senicapoc (Standard)
MBS386855-01Senicapoc (ICA-17043)
A11568-50Senicapoc (ICA-17043) 50mg
A11568-10Senicapoc (ICA-17043) 10mg
A11568-5Senicapoc (ICA-17043) 5mg
BS300121Senicapoc - Bio-X TM
A11568-200Senicapoc (ICA-17043) 200mg
A11568-100Senicapoc (ICA-17043) 100mg

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